Nano-Mechanical Eukaryotic Cell Behavior by Finite Element Modeling

E. El Kennassi, F. El Kennassi, M. A. Dirhar, E. Azelmad, K. I. Janati, L. Bousshine 

Volume 7: Issue 2, July 2020, pp

Abstract - There is a need to understand the eukaryotic cell mechanics behavior. The used methods are nanoindentation and atomic force microscopy AFM. The first method gives displacement information at the size ranging between 10-9 and 10-3 meter for a load ranging from 10-7 to 10 Newton. The second method gives information at the size ranging between 10-11 and 10-7 meter for a load ranging from 10-12 to 10-5 Newton. This work concerns the nanoindentation eukaryotic cell simulation using COMSOL Multiphysics and the relation to AFM. We investigate the nano-mechanical cell behavior by the finite element mechanics continuum implementation. We created a 2D cell model which is constrained vertically at the bottom. The cytoplasm was assimilated to a hyperelastic material model. The contact between nanoindenter and cell is simulated as source boundary. We also incorporated to the model a circular section which represents the nucleus. This later will influence the mechanical response and it was chosen to be elastic. Results obtained after modeling and simulation are in good agreements with those obtained experimentally.

Index terms - Multiphysics, Eukariotic cell, Nanoindentation, Modeling, COMSOL, Finite Element method.
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