Nano-Mechanical Eukaryotic Cell Behavior by Finite Element Modeling

E. El Kennassi, F. El Kennassi, M. A. Dirhar, E. Azelmad, K. I. Janati,
Volume 7: Issue 3, August 2020, pp 61-67


Author's Information
E. El Kennassi1 
Corresponding Author
1Mechanics Department, ENSEM, Hassan II University of Casablanca, Morocco.
essaid.elkennassi@ieee.org

M. A. Dirhar1, E. Azelmad1
1Mechanics Department, ENSEM, Hassan II University of Casablanca, Morocco.


F. El Kennassi2,3
2Cardiovascular Surgeon Moulay Youssef Hospital, Rabat, Morocco.

3Pharmacology and Toxicology Department, Faculty of medicine, Mohammed V University of Rabat, Morocco.


K. I. Janati4
4Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University of Fez, Morocco.


Review Article -- Peer Reviewed
Published online – 20 August 2020

Open Access article under Creative Commons License

Cite this article – E. El Kennassi, F. El Kennassi, M. A. Dirhar, E. Azelmad, K. I. Janati, “Nano-Mechanical Eukaryotic Cell Behavior by Finite Element Modeling”, International Journal of Analytical, Experimental and Finite Element Analysis, RAME Publishers, vol. 7, issue 3, pp. 61-67, August 2020.
https://doi.org/10.26706/ijaefea.3.7.20200803


Abstract:-
The cell mechanics behavior must be understood by the scientific community. There is two used methods: nanoindentation and atomic force microscopy AFM. The first one gives displacement between 10-9 and 10-3 meter corresponding to a load from 10-7 to 10 Newton. The second one gives displacement between 10-11 and 10-7 meter corresponding to a load ranging from 10-12 to 10-5 Newton. This work gives the nanoindentation eukaryotic cell simulation by the use of the commercial software: COMSOL Multiphysics and we give the relation to AFM. The nano-mechanical cell behavior was investigated using the finite element method, especially, we implement on it, the mechanics continuum. First, we created the 2D cell model. This model was constrained vertically at the bottom. We used hyperelastic model for the cytoplasm. Nanoindenter and cell contact was assumed to be a source boundary. In the second part of this work, we incorporated a circular section to the model. This circular section represents the nucleus chosen to be elastic. We then show that nucleus influences the cell mechanical response. After modeling and simulation, we obtain results in good agreements with those obtained experimentally.
Index Terms:-
Multiphysics, eukaryotic cell, nanoindentation, modeling, COMSOL, finite element method
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